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Author:
Date:
2015-08-05
[Abstract] This protocol aims to study intercellular transport of mitochondria, dynamic cellular organelles via tunnelling nanotubes (TNT), a cell membrane extension of cytoskeletal elements. The nanotubular bridges or the tunnelling nanotube highways are one of the emerging new cell-to-cell communication systems which mediates exchange of cellular materials, most importantly as in our observation, mitochondria. Mesenchymal stem cells (MSC) have been well studied to be endowed with a highly efficient intercellular mitochondrial donation ability and this property is now proven crucial to its functional role of rescue in cellular therapy.
[摘要] 此协议旨在研究线粒体，动态细胞器通过隧道纳米管（TNT），细胞骨架元素的细胞膜扩展的细胞间运输。 纳米管桥或隧道纳米管高速公路是新兴的新的细胞到细胞通信系统之一，其介导细胞材料的交换，最重要的是在我们的观察中，线粒体。 间充质干细胞（MSC）已经被充分研究以赋予高效的细胞间线粒体捐赠能力，并且这种性质现在被证明对于其在细胞治疗中的挽救的功能作用是至关重要的。
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