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10x Tris Buffered Saline (TBS)

10x Tris缓冲盐水(TBS)

Company: Bio-Rad Laboratories
Catalog#: 1706435
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Western Blot for Detecting Phosphorylated STAT3
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2011-08-20
[Abstract]  The STAT3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors and is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. STAT3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Western blot is most commonly used to detect the activation of STAT3 by using an antibody that is specific for the phosphorylated tyrosine705. [摘要]  STAT3转录因子是许多细胞因子和生长因子受体的重要信号分子,并且在许多人肿瘤中被组成型激活,并且具有致癌潜力和抗凋亡活性。 STAT3被Tyr705处的磷酸化激活,其诱导二聚化,核转位和DNA结合。 蛋白质印迹最常用于通过使用对磷酸化酪氨酸特异的抗体来检测STAT3的活化。

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