TNP11-OVA

Company: BioTechniques

Catalog#: T-5051-10

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IgE-mediated Chronic Allergic Inflammation (IgE-CAI)

Author:

Yasuyo Harada and Masato Kubo,

Date:

2012-10-05

[Abstract] This system is one of a chronic allergic inflammation model. A single subcutaneous injection of antigens elicits a delayed-type response manifested by ear swelling. The entire response consists of three phases: Immediate, late, and chronic. The early-phase swelling peak within 1 h after allergen challenge is followed by the late-phase swelling 6-10 h late. Importantly, the ear swelling at the late-phase started on day2 and peak on day4. This late-phase ear swelling response is defined as IgE-mediated chronic allergic inflammation (IgE-CAI) and mainly regulated by basophils. [摘要] 该系统是慢性过敏性炎症模型之一。单次皮下注射抗原引起由耳肿胀表现的延迟型反应。整个反应包括三个阶段：即时，晚期和慢性。在变应原攻击后1小时内的早期肿胀峰值之后是晚期6-10小时的晚期肿胀。重要的是，后期的耳肿胀在第2天开始，在第4天达到峰值。这种晚期耳肿胀反应定义为IgE介导的慢性过敏性炎症（IgE-CAI），并且主要由嗜碱性粒细胞调节。

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TNP11-OVA

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