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Author:
Date:
2015-12-05
[Abstract] The visceral adipose tissue (VAT) has been shown to play an important role in various biological functions. It is a storage depot for nutrients and it is an important endocrine organ producing hormones that control systemic metabolism (McGown et al., 2014). Importantly, following diet-induced obesity, VAT accumulates a large number of activated immune cells, which produce cytokines that drive chronic systemic inflammation and promote insulin resistance (Johnson et al., 2012; Wensveen et al., 2015). VAT therefore plays a key role in metabolic, endocrinological and immunological research. To show the importance of this organ in various research models, one may surgically remove the organ in a procedure called VATectomy. This protocol describes the technical ...
[摘要] 内脏脂肪组织（VAT）已显示在各种生物功能中发挥重要作用。 它是营养物质的储存库，它是产生控制系统代谢的激素的重要内分泌器官（McGown等人，2014）。 重要的是，在饮食诱发的肥胖症之后，VAT累积大量的活化免疫细胞，其产生驱动慢性全身炎症和促进胰岛素抵抗的细胞因子（Johnson等人，2012; Wensveen等人 al。，2015）。 因此，增值剂在代谢，内分泌和免疫学研究中起着关键作用。 为了显示该器官在各种研究模型中的重要性，可以在称为VATectomy的手术中手术切除器官。 该协议描述了有效的VAT切除小鼠的perigonadal脂肪垫所需的技术程序。
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