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Sonic dismembrator

声波解密器

Company: Thermo Fisher Scientific
Catalog#: 100
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Activation of ER-regulated Fusion Proteins In Vivo
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2011-12-20
[Abstract]  Regulatable protein fusions can be made by attaching the hormone binding domain of the estrogen receptor to the N or C-terminus of a protein of interest. Activation of such ER-fusion proteins in vivo can be achieved by daily administration of a synthetic ligand, 4-hydroxytamoxifen (4OHT), via intraperitoneal (i.p.) injection. [摘要]  可调节的蛋白质融合体可以通过将雌激素受体的激素结合结构域连接到目标蛋白质的N或C末端来制备。 这种ER-融合蛋白在体内的激活可以通过每日通过腹膜内(i.p.)注射施用合成配体4-羟基他莫昔芬(4OHT)来实现。

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