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Author:
Date:
2016-07-05
[Abstract] Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Being overweight or obese for a woman at the time she is diagnosed with breast cancer is linked to a high risk of recurrence regardless of treatment factors. In rodents, high body weight is also associated with increased incidence of spontaneous and chemically induced tumors. To study the complex interaction between the mammary epithelia and the microenvironment, with a focus on the mechanism underlying the role obesity plays in the regulation of the cancer stem cell traits and the development of mammary cancer in vivo, we have established a diet-induced obesity (DIO) rat model of breast cancer (Chang et al., 2015).
[摘要] 肥胖已经与乳腺癌进展相关，但潜在的机制仍然是模糊的。 当她被诊断患有乳腺癌时，对于女性的超重或肥胖与不考虑治疗因素的高复发风险相关。 在啮齿动物中，高体重也与自发和化学诱导的肿瘤的发生率增加相关。 为了研究乳腺上皮和微环境之间的复杂相互作用，重点在于肥胖在调节癌症干细胞特性和体内乳腺癌的发展中起作用的机制，我们 已经建立了乳腺癌的饮食诱导的肥胖（DIO）大鼠模型（Chang等人，2015）。
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