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Minimum essential medium

最低基本培养基

Company: Thermo Fisher Scientific
Catalog#: 51200-046
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Luminescence-based Antiviral Assay for Hepatitis E Virus
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2014-08-05
[Abstract]  Hepatitis E virus (HEV) is one of the main causes of acute hepatitis worldwide. Infections are particularly severe in pregnant women and chronic hepatitis E is known to occur in immunocompromised patients. Current therapy (ribavirin or pegylated alpha interferon) has severe side effects and cannot be employed in all patients. In order to evaluate potential new inhibitors of HEV replication, a luminescence-based replicon assay is particularly useful since it offers a rapid read-out and does not pose any biosafety risks (Debing et al., 2014). [摘要]  戊型肝炎病毒(HEV)是全世界急性肝炎的主要原因之一。 感染在孕妇中特别严重,已知慢性戊型肝炎发生在免疫受损的患者中。 目前的治疗(利巴韦林或聚乙二醇化α干扰素)具有严重的副作用,不能用于所有患者。 为了评价潜在的新的HEV复制抑制剂,基于发光的复制子测定法是特别有用的,因为其提供了快速读出,并且不会引起任何生物安全风险(Debing等人,2014) 。

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