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Author:
Date:
2014-06-05
[Abstract] Innate immune cells sense pathogen and danger-associated molecular patterns (PAMPs and DAMPs) through a range of innate immune pattern recognition receptors (PRRs). One type of PRRs are the Nod-like receptors (NLRs), which form inflammasomes; a molecular platform required for the recruitment and activation of Caspase-1, which in turn cleaves and activates IL-1β, IL-18. Examples of inflammasome forming NLRs are NLRP3, NLRP1, NAIP and NLRC4. We can easily identify new inflammasome activators by performing the following protocol.
[摘要] 先天免疫细胞通过一系列先天免疫模式识别受体（PRR）感知病原体和危险相关分子模式（PAMP和DAMP）。 一种类型的PRR是Nod样受体（NLR），其形成炎症体; 募集和激活Caspase-1所需的分子平台，其反过来切割和激活IL-1β，IL-18。 形成NLR的炎性体的实例是NLRP3，NLRP1，NAIP和NLRC4。 我们可以通过执行以下协议轻松识别新的inflammasome激活剂。
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