| IgE-mediated Chronic Allergic Inflammation (IgE-CAI)
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Author:
Date:
2012-10-05
[Abstract] This system is one of a chronic allergic inflammation model. A single subcutaneous injection of antigens elicits a delayed-type response manifested by ear swelling. The entire response consists of three phases: Immediate, late, and chronic. The early-phase swelling peak within 1 h after allergen challenge is followed by the late-phase swelling 6-10 h late. Importantly, the ear swelling at the late-phase started on day2 and peak on day4. This late-phase ear swelling response is defined as IgE-mediated chronic allergic inflammation (IgE-CAI) and mainly regulated by basophils.
[摘要] 该系统是慢性过敏性炎症模型之一。 单次皮下注射抗原引起由耳肿胀表现的延迟型反应。 整个反应包括三个阶段：即时，晚期和慢性。 在变应原攻击后1小时内的早期肿胀峰值之后是晚期6-10小时的晚期肿胀。 重要的是，后期的耳肿胀在第2天开始，在第4天达到峰值。 这种晚期耳肿胀反应定义为IgE介导的慢性过敏性炎症（IgE-CAI），并且主要由嗜碱性粒细胞调节。
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| Mast Cell Dependent Airway Hyperresponsiveness (AHR)
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Author:
Date:
2012-10-05
[Abstract] Asthma is a complex phenotype that involves multiple mechanisms, including adaptive and innate immunity as well as physiological and mechanical changes in the airways. In the models of asthma induced by sensitization and aerosolized allergen exposure in the absence of adjuvant, mast cells facilitate the development of in ammation and airway hyper-responsiveness. This model is useful to analysis of function of mast cells in AHR.
[摘要] 哮喘是一种复杂的表型，涉及多种机制，包括适应性和先天性免疫以及气道的生理和机械变化。 在不存在佐剂的情况下，在致敏和气雾化的过敏原暴露诱导的哮喘模型中，肥大细胞促进了炎症和气道高反应性的发展。 该模型可用于分析AHR中肥大细胞的功能。
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