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Author:
Date:
2016-01-05
[Abstract] Galectin-3 is a member of a class of proteins termed Galectins, characterized by their ability to bind glycans containing β-galactose (Cummings and Liu, 2009). Galectin-3 binds preferentially to proteoglycans terminating with N-acetyllactosamine (LacNAc) chains (i.e., tandem repeats of galactose) (Newlaczyl and Yu, 2011). Galectin-3 is unique among the galectins in its chimeric structure. It shares a conserved carbohydrate recognition domain (CRD) with the other galectins, but has a long amino-terminal tail that is thought to be involved in protein aggregation. It can also form homodimers through its CRD (Cummings and Liu, 2009). Galectin-3 has been found to have diverse functions in tumorigenesis including: signaling, apoptosis inhibition, immune suppression, cell growth, and ...
[摘要] Galectin-3是称为Galectins的一类蛋白质的成员，其特征在于它们结合含有β-半乳糖的聚糖的能力（Cummings和Liu，2009）。 Galectin-3优先结合以N-乙酰乳糖胺（LacNAc）链（即半乳糖的串联重复）终止的蛋白聚糖（Newlaczyl和Yu，2011）。 Galectin-3在其嵌合结构中的半乳凝素中是独一无二的。它与其他半乳凝素共享保守的碳水化合物识别结构域（CRD），但具有被认为参与蛋白质聚集的长氨基末端尾部。它也可以通过CRD形成同型二聚体（Cummings和Liu，2009）。已经发现Galectin-3在肿瘤发生中具有多种功能，包括：信号转导，凋亡抑制，免疫抑制，细胞生长和转移等。 ...
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