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Chitin from shrimp shells

甲壳素从虾壳

Company: Sigma-Aldrich
Catalog#: C9752
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Chitin-challenged Mice Model to Study M2 Macrophages Polarization
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2015-09-05
[Abstract]  Chitin is a key component of insects, fungi, and house-dust mites. Chitin has been shown to induce M2-type immune responses in vivo. Intranasal or intraperitoneal (i.p.) administration of chitin particles results in infiltration of eosinophils to the local sites and activation of macrophages with a M2 phenotype. Chitin-challenged mice model can be used to induce M2 macrophages polarization and thus to analyze the M2 phenotype from isolated peritoneal cells. [摘要]  几丁质是昆虫,真菌和房尘螨的关键组分。 几丁质已显示在体内诱导M2型免疫应答。 鼻内或腹膜内(i.p.)施用几丁质颗粒导致嗜酸性粒细胞渗透到局部部位并激活具有M2表型的巨噬细胞。 几丁质攻击的小鼠模型可以用于诱导M2巨噬细胞极化,从而分析来自分离的腹膜细胞的M2表型。

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