|
Author:
Date:
2014-06-05
[Abstract] The knowledge that many pathogens rely on cell-to-cell communication mechanisms known as quorum sensing, opens a new disease control strategy: quorum quenching. Here we present a purification protocol for molecules excreted by a group of Gram-positive zoonotic pathogen bacteria, the ‘Staphylococcus intermedius group’, that suppress the quorum sensing signaling and inhibit the growth of a broad spectrum of Gram-negative beta- and gamma-proteobacteria. These compounds were isolated from Staphylococcus delphini (S. delphini). They represent a new class of quorum quenchers with the chemical formula N-[2-(1H-indol-3-yl)ethyl]-urea and N-(2-phenethyl)-urea, which we named yayurea A and B, respectively. These substances can be isolated and ...
[摘要] 许多病原体依赖于被称为群体感应的细胞间通信机制的知识，开启了一种新的疾病控制策略：群体猝灭。 在这里，我们提出了一组由革兰氏阳性动物传染病原体细菌分泌的分子的纯化方案，所述细菌是抑制群体感应信号传导并抑制广谱革兰氏菌的生长的'中间体葡萄球菌 - 阴性β-和γ-变形细菌。 这些化合物从葡萄球菌delphini （ S. delphini ）中分离。 它们代表一类新的具有化学式N - [2-（1H-吲哚-3-基）乙基] - 脲和N，N-二 - - （2-苯乙基） - 脲，其分别命名为yayurea A和B. 这些物质可以使用这种可扩大的纯化方法从培养物上清液中分离和纯化
|