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Author:
Date:
2013-07-20
[Abstract] Steroid hormone receptors, for example estradiol receptor, act like transcription factors. In the cell, steroids bind to a specific receptor. Upon ligand binding, many steroid receptors dimerize and enter nuclei where they bind specific DNA sequences called Hormone Responsive Elements (HRE) and regulate gene transcription. ER is able to bind DNA sites that are not Estrogen Responsive Elements (ERE) so regulating also the transcription of genes that are not classically controlled by estrogens.
[摘要] 类固醇激素受体，例如雌二醇受体，像转录因子一样起作用。 在细胞中，类固醇与特异性受体结合。 在配体结合时，许多类固醇受体二聚化并进入细胞核，其中它们结合称为激素应答元件（HRE）的特异性DNA序列并调节基因转录。 ER能够结合不是雌激素反应元件（ERE）的DNA位点，从而也调节不经典地由雌激素控制的基因的转录。
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