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Gentamicine
Company: Genta-Gobens; Laboratorios Normon
Catalog#: #999037
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An Operant Conditioning Model Combined with a Chemogenetic Approach to Study the Neurobiology of Food Addiction in Mice
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2020-10-05
[Abstract]  The study of food addiction comprises 3 hallmarks that include the persistence to response without an outcome, the strong motivation for palatable food, and the loss of inhibitory control over food intake that leads to compulsive behavior in addicted individuals. The complex multifactorial nature of this disorder and the unknown neurobiological mechanistic correlation explains the lack of effective treatments. Our operant conditioning model allows deciphering why some individuals are vulnerable and develop food addiction while others are resilient and do not. It is a translational approach since it is based on the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and the Yale Food Addiction Scale (YFAS 2.0). This model allows to evaluate the addiction criteria in 2 ... [摘要]  [摘要]对食物成瘾的研究包括3个标志，包括对反应的坚持 没有结果，就很难获得可口食物的动力，失去对食物摄入的抑制性控制会导致成瘾者的强迫行为。这种疾病的复杂的多因素性质和未知的神经生物学机制相关性解释了缺乏有效的治疗方法。我们的操作员条件模型可以解释为什么有些人容易受到伤害并发展成瘾，而另一些人却坚强不屈。由于它基于《精神疾病诊断和统计手册》第5版（DSM-5）和耶鲁大学食物成瘾量表（YFAS 2.0），因此是一种翻译方法。该模型可以通过将其分为以下两种情况来评估成瘾标准：在两个时间点上的早期和晚期：1）在没有食物的时期内对反应的持续性； ...

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