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Company: Patterson Scientific WAG unit
Catalog#: 78909457
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Minimally Invasive Oral Surgery Induction of the FRICT-ION Chronic Neuropathic Pain Model
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2020-04-20
[Abstract]  An easily induced preclinical trigeminal neuropathic nerve injury model is described here for the study of chronic pain, the model acronym FRICT-ION (Foramen Rotundum Inflammatory Constriction Trigeminal InfraOrbital Nerve). In patients, neuropathic pain is thought to be related to vascular alignment or multiple sclerosis along this small trigeminal nerve branch (V2) innervating the maxillary teeth and middle third of the face. With no detectable outward physical signs, the FRICT-ION model is ideal for blinded studies. The acronym FRICT-ION applied relates to the persistence of the trigeminal neuropathic pain model likely due to sliding irritation with normal chewing in the mice. A step-by-step method to induce the mild ... [摘要]  [摘要 ] 一种容易诱发临床前三叉神经性神经损伤模型中描述了在此对于研究的慢性疼痛，Ť 他模型缩写FRICT-ION （˚F Oramen ř Otundum 我Nflammatory Ç Onstriction Ť Rigeminal 我NFRA ö Rbital Ñ ERVE），在患者，神经性疼痛被认为与支配上颌牙齿和中三分之一o的小三叉神经分支（V2）上的血管排列或多发性硬化有关 F中的人脸。没有检测到对外体征，该FRICT-ION模式非常适合盲法研究。缩写FRICT-ION应用RELA 维护设备到持久性的三叉神经性疼痛模型可能是由于滑有刺激性，一般正常的咀嚼中的小鼠，一种步骤一步的方法诱导的慢性轻度的啮齿动物神经疼痛模型描述了这里。在手术进行口服通过一个很小的手术狭缝处的脸颊折痕对齐铬肠线缝合刺激沿神经，因为它穿入该模型允许使用von Frey细丝测试至少10-14周（100天）的非诱发性主观措施和诱发性定量机械性超敏反应（异常性疼痛），在与焦虑相关的3-6周内会出现焦虑和抑郁行为尽管根据在可用的急性动物模型中进行的测试，许多止痛药均以失败告终，但更稳定，更容易复制的三叉神经炎。压缩模式保守党是是更好的适合了解这两种机理而Affec 略去组件的神经伤病引致诱发的慢性神经性疼痛状态以及在更理想的临床前试验的新型非阿片类止痛疗法。

[背景 ] ...

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