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Author:
Date:
2018-04-05
[Abstract] Spinal cord injury (SCI) is characterized by multiple sensory/motor impairments that arise from different underlying neural mechanisms. Linking specific sensory/motor impairments to neural mechanism is limited by a lack of direct experimental access to these neural circuits. Here, we describe an experimental model which addresses this shortcoming. We generated a mouse model of chronic spinal cord injury that reliably reproduces spasticity observed after SCI, while at the same time allows study of motor impairments in vivo and in an in vitro preparation of the spinal cord. The model allows for the combination of mouse genetics in in vitro and in vivo conditions with advanced imaging, behavioral analysis, and detailed electrophysiology, techniques which ...
[摘要] 脊髓损伤（SCI）的特点是由不同的潜在神经机制引起的多种感觉/运动损伤。 将特定的感觉/运动障碍与神经机制联系起来受限于缺乏对这些神经回路的直接实验访问。 在这里，我们描述了一个解决这个缺点的实验模型。 我们产生了一种慢性脊髓损伤的小鼠模型，其可靠地再现SCI后观察到的痉挛状态，同时允许研究运动损伤体内和体外制剂 的脊髓。 该模型允许将体外和体内条件下的小鼠遗传与高级成像，行为分析和详细的电生理学技术相结合，这些技术在常规SCI中不易应用 楷模。
【背景】脊髓损伤导致了毁灭性的感官 - ...
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