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Polycarbonate Tube with Polypropylene Cap

Company: Techno Plas
Catalog#: P5016SU
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Transplantation of Fecal Microbiota Shaped by Diet
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2018-01-05
[Abstract]  Alterations in diet and gut microbial ecology underlie the pathogenesis of type 1 diabetes (T1D). In the non-obese diabetic (NOD) mouse, we found high concentrations of bacterial metabolites acetate and butyrate in blood and faeces correlated with protection from disease. We reconstituted germ free (GF) NOD mice with fecal bacteria from protected NOD mice fed with high acetate- and butyrate-yielding diets, to test whether the transferred gut microbiota protect against the development of T1D. GF NOD mice that received a microbiota shaped by high acetate- but not butyrate-yielding diet showed a marked protection against diabetes. This fecal transplantation assay demonstrated the potential for a dietary technology to reshape the gut microbiota that enables specific bacteria to transfer ... [摘要]  饮食和肠道微生物生态学的改变是1型糖尿病(T1D)发病的基础。 在非肥胖糖尿病(NOD)小鼠中,我们发现血液和粪便中高浓度的乙酸和丁酸的细菌代谢物与防止疾病相关。 我们使用来自受保护的NOD小鼠的粪便细菌重建无菌(GF)NOD小鼠,饲喂高乙酸盐和丁酸盐产生的饮食,以测试转移的肠道微生物群是否防止T1D的发展。 GF NOD小鼠接受由高乙酸盐但不是丁酸盐产生饮食形成的微生物群显示出对糖尿病的显着保护。 这种粪便移植试验表明,饮食技术可以重塑肠道微生物群,使特定的细菌能够转移对T1D的保护。


【背景】已经在各种各样的疾病和病况中观察到肠道微生物群的变化。由于共生菌和致病菌之间的比例变化,肠道益生菌微生物群体失去了体内平衡。当微生物的组成变化很大时,可以观察到生物异常,某些种类的数量增加或减少(Clemente等,2012; Rajilic-Stojanovic,2013)。此外,肠道微生物群组成(其可能影响代谢物如SCFAs)的变化与许多炎性疾病有关(Clemente等人,2012),包括T1D(de Goffau等人 >,2013; Endesfelder ...

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