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Individually Ventilated Animal Caging System

Company: CITIZEN INDUSTRIES
Catalog#: 11
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Sensitive Estimation of Flavor Preferences in STFP Using Cumulative Time Profiles
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2017-11-05
[Abstract]  Social transmission of food preference (STFP) is observed among rodents between a demonstrator and a naïve hungry observer. During social interaction, hungry observer receives information about safety of the food consumed by the demonstrator. This task has been implemented to develop a single trial non-aversive learning task in order to test hippocampus dependent non-spatial memory in rodents. In this protocol, we describe some novel modifications to the conventional STFP protocol and analysis for more sensitive estimation of change in preferences. Using this method, preference trends can be observed for weeks after training, allowing one to probe the role of systems consolidation (SC) in declarative memory that is relatively independent of spatial navigation. [摘要]  在示威者和天真饥饿的观察者之间的啮齿动物中观察到食物偏好(STFP)的社交传播。 在社交互动中,饥饿的观察者收到有关示威者消耗食物安全的信息。 为了测试啮齿类动物的海马依赖性非空间记忆,已经实施了这个任务来开发单一试验的非厌恶性学习任务。 在这个协议中,我们描述了对传统STFP协议的一些新的修改,并分析了对偏好变化的更敏感的估计。 使用这种方法,可以在训练后的几个星期观察偏好趋势,使人们可以探索系统整合(SC)在相对独立于空间导航的声明性记忆中的作用。
【背景】Bennet G Galef Jr.在20世纪70年代为了测试记忆机制而开发了基于STFP的大鼠行为模式,并且从那以后,它已经用大鼠和小鼠进行了各种研究(Galef Jr,1977; Clark等人, 2002; Wrenn等人,2003; Ross和Eichenbaum,2006; Smith等人,2007; Choleris等人, ,2011;Lesburguères et al。,2011; ...

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