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Company: Fine Science Tools

Catalog#: 15000-08

Assessment of Chemosensory Response to Volatile Compounds in Healthy, Aged, and Neurodegenerative Caenorhabditis elegans Models

Cira Crespo and Roberto Grau

Published online: 2023-05-05

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Spared Nerve Injury Model of Neuropathic Pain in Mice

Author:

Joseph Cichon, Linlin Sun and Guang Yang,

Date:

2018-03-20

[Abstract] Experimental models of peripheral nerve injury have been developed to study mechanisms of neuropathic pain in living animals. The spared nerve injury (SNI) model in rodents is a partial denervation model, in which the common peroneal and tibial nerves are injured, producing consistent and reproducible tactile hypersensitivity in the skin territory of the spared, intact sural nerve. SNI-operated mice require less force applied to the affected limb to elicit a withdrawal behavior as compared to sham mice. This effect is observed as early as 2 days after surgery and lasts for at least 1 month. We describe detailed surgical procedures to establish the SNI mouse model that has been widely used for investigating mechanisms of neuropathic pain. [摘要] 等人，1990; Kim和Chung，1992 ）。部分去神经支配模型使研究人员能够研究不同组的神经元细胞和非神经元细胞的结构和功能变化。研究可以在神经性疼痛的起始，进展（也称为急性）和维持（慢性）阶段以及在沿着疼痛途径的不同解剖部位期间进行，包括远侧与近侧周围神经纤维，背根神经节，脊髓绳索，皮质下和皮层区域。备用神经损伤（SNI）模型包括部分神经损伤，其中腓总神经和胫神经受损，在腓肠神经部位产生一致且可再现的疼痛超敏反应（Decosterd和Woolf，2000; Shields等人，，2003）。该模型已被证明是有力的，证明了机械敏感性和热响应性的行为测量值的实质和长期变化（Bourquin等人，2006）。这些特征与临床描述的神经性疼痛疾病的主要症状密切相似。

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