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Author:
Date:
2020-12-05
[Abstract] Epidemiological studies robustly show the beneficial effects of maternal exercise in reducing maternal birth complications and improving neonatal outcomes, though underlying mechanisms remain poorly understood. To facilitate mechanistic exploration, a protocol for maternal exercise of mice is established, with the regimen following the exercise guidelines for pregnant women. Compared to volunteer wheel running, treadmill running allows precise control of exercise intensity and duration, dramatically reducing variations among individual mouse within treatments and facilitating translation into maternal exercise in humans. Based on the maximal oxygen consumption rate (VO2max) before pregnancy, the treadmill exercise protocol is separated into three stages: early stage (E1.5 to E7.5 at 40% ...
[摘要] [摘要]流行病学研究有力地表明了孕产妇运动对减少孕产妇并发症和改善新生儿结局的有益作用，尽管其潜在的机制仍知之甚少。为了促进机械探索，建立了小鼠母体运动的方案，该方案遵循孕妇的运动准则。与自愿轮式跑步相比，跑步机可精确控制运动强度和持续时间，从而大大减少了治疗过程中单个鼠标之间的差异，并有利于人类进行母体运动。基于最大耗氧率（VO 2 最大值）怀孕前，平板运动协议被分成三个阶段：早期（E1.5至E7.5在40％VO 2在65％最大），中间阶段（E8.5至E14.5 VO 2最大值）和妊娠后期（E15.5至最高50％VO 2出生），表明对产妇健康和胎儿发育具有持续的有益作用。该协议对于使用小鼠作为实验模型的孕产妇跑步运动标准化非常有用。
关键字：孕妇运动，怀孕，跑步机，最大VO 2 ，小鼠，方案
[背景]母体暴露于不利的环境刺激会导致后代发生各种生理变化（Hay等，2016；Walejko等，2019；Battarbee等，2020 ），包括后代易患肥胖症和肥胖症。 2型糖尿病（Godfrey等，2017; Wesolowski等，2018 ）。 体育锻炼非常容易获得，并且是对抗成人饮食引起的肥胖症的重要治疗工具（Peres Valgas da ...
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