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Author:
Date:
2014-09-20
[Abstract] Amyloid-β (Aβ)-containing plaques accumulate in the brains of patients with Alzheimer’s disease (AD). Studies in transgenic mice which over-express amyloid precursor protein and presenilin 1 (APP/PS1 mice) have suggested that T cells that infiltrate the brain may influence the development of Aβ plaques and associated cognitive dysfuncation. Active immunization with Aβ peptides and adjuvants has been evaluated as a therapy for AD, based on the premise that it induces Aβ-specific antibodies that may help to clear the Aβ plaques. However, immunization with Aβ peptides and adjuvants also promotes the development of Aβ-specific T cells (McQuillan et al., 2010) and there is evidence that Aβ-specific T cell may influence the development of Aβ plaques and disease progression in AD ...
[摘要] 含有淀粉样蛋白β（Aβ）的斑块积聚在患有阿尔茨海默病（AD）的患者的脑中。过表达淀粉样蛋白前体蛋白和早老蛋白1（APP/PS1小鼠）的转基因小鼠的研究已经表明浸润大脑的T细胞可能影响Aβ斑块和相关认知功能障碍的发展。使用Aβ肽和佐剂的主动免疫已被评估为AD的治疗，基于其诱导可能有助于清除Aβ斑块的Aβ特异性抗体的前提。然而，用Aβ肽和佐剂免疫也促进Aβ特异性T细胞的发展（McQuillan等人，2010），并且有证据表明Aβ特异性T细胞可能影响Aβ斑块的发展和AD患者的疾病进展。在小鼠模型中，分泌IFN-γ（Th1细胞）的Aβ特异性T细胞已显示增强斑块负荷（Browne等人，2013）。已经在体外极化为Th1，Th2，Th17或Treg细胞的Aβ特异性T细胞的过继转移可用于体内检查这些细胞的功能。
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