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PE Mouse Anti-Human CD114 Clone LMM741 (RUO)

PE小鼠抗人CD114克隆LMM741(RUO)

Company: BD
Catalog#: 554538
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In vivo Lineage-tracing Studies in a Cancer Stem Cell Population in Neuroblastoma
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Date:
2014-04-20
[Abstract]  Tumors are comprised of heterogeneous subpopulations that may exhibit differing capacity for differentiation, self-renewal, and tumorigenicity. In vivo lineage-tracing studies are a powerful tool for defining the role of tumor subpopulations in tumor growth and as targets for therapeutic agents. This protocol describes using a neuroblastoma cancer cell line transduced with two different fluorescent proteins (GFP and tdTomato) to track the specific contributions of cells expressing the GCSF receptor (CD114+) or not (CD114-) on tumor growth in vivo.
[摘要]  肿瘤由异质亚群组成,其可以表现出不同的分化,自我更新和致瘤性能力。 体内谱系追踪研究是定义肿瘤亚群在肿瘤生长中的作用和作为治疗剂靶标的有力工具。 该方案描述了使用用两种不同的荧光蛋白(GFP和tdTomato)转导的神经母细胞瘤癌细胞系来追踪表达GCSF受体(CD114 + sup)+或CD114(sup)+的细胞的特异性作用 )对肿瘤生长的作用。

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