Bis(2,2,2-trifluoroethyl) ether

Company: Sigma-Aldrich

Catalog#: 287571

Assessment of Chemosensory Response to Volatile Compounds in Healthy, Aged, and Neurodegenerative Caenorhabditis elegans Models

Cira Crespo and Roberto Grau

Published online: 2023-05-05

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The Repeated Flurothyl Seizure Model in Mice

Author:

Russell J. Ferland,

Date:

2017-06-05

[Abstract] Development of spontaneous seizures is the hallmark of human epilepsy. There is a critical need for new epilepsy models in order to elucidate mechanisms responsible for leading to the development of spontaneous seizures and for testing new anti-epileptic compounds. Moreover, rodent models of epilepsy have clearly demonstrated that there are two independent seizure systems in the brain: 1) the forebrain seizure network required for the expression of clonic seizures mediated by forebrain neurocircuitry, and 2) the brainstem seizure network necessary for the expression of brainstem or tonic seizures mediated by brainstem neurocircuitry. In seizure naïve animals, these two systems are separate, but developing models that can explore the intersection of the forebrain and brainstem seizure ... [摘要] 自发性发作的发展是人类癫痫的标志。为了阐明导致自发性发作发展的机制和用于测试新的抗癫痫化合物，新的癫痫模型是至关重要的。此外，癫痫的啮齿动物模型已经清楚地表明脑中有两个独立的发作系统：1）前脑神经电路介导的阵挛性发作所需的前脑发作网络，以及2）脑干发作网络脑干神经电路介导的脑干或强直性癫痫发作。在癫痫天真动物中，这两个系统是分开的，但是可以探索前脑和脑干癫痫发作系统的交叉点或用于阐明负责将这两个癫痫发作系统结合在一起的发展模型可能有助于我们理解：1）癫痫发作是如何变得更加复杂的加班，以及2）由于许多心肺系统局限在脑干中，因为将癫痫发作从前脑癫痫发作系统扩散到脑干癫痫发作系统，可能在SUDEP中起重要作用，癫痫突发意外死亡（SUDEP）。如这里所述，癫痫发生的重复荧光癫痫模型可能有助于提供对这些重要的癫痫问题的了解，以及了解自发性发作如何发展。

背景癫痫是由无端自发性癫痫发作定义的复杂多因素疾病。大约三分之二的癫痫患者成功地用抗惊厥药物治疗方案治疗，其余三分之一的人仍然发现癫痫发作（Kwan and Brodie，2000; Lindsten等人，2001; Kwan et al。 al。，2010; Loscher等人，2013; ...

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Bis(2,2,2-trifluoroethyl) ether

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