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Stainless Steel Grid Floor for Rat or Small Primate

Company: Med Associates
Catalog#: ENV-005
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Cued Rat Gambling Task
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2017-02-05
[Abstract]  The ability of salient cues to serve as powerful motivators has long been recognized in models of drug addiction, but little has been done to investigate their effects on complex decision making. The Cued rat Gambling Task (CrGT) is an operant behavioural task which pairs salient, audiovisual cues with the delivery of sucrose pellet rewards on complex schedules of reinforcement that involve both sugar pellet ‘wins’ and timeout penalty ‘losses’. The task was designed with the intention of providing insight into the influence of such cues on decision making in a manner that models human gambling. [摘要]  突出线索作为强大动机的能力早已被药物成瘾模型所认可,但很少有人调查其对复杂决策的影响。 Cued大鼠赌博任务(CrGT)是一个操作性行为任务,它将突出的视听线索与提供糖丸“胜利”和超时罚款“损失”的复杂强化时间表上提供蔗糖丸奖励。 这项任务的目的是为了提供洞察这种线索对决策的影响,以模拟人类赌博的方式。
【背景】虽然最近已经开发了许多捕捉赌博式行为的不同方面的啮齿动物行为模式,但是尽管药物配对提示在成功的实验室模型中发挥了核心作用,但是线索在将风险偏向于风险选择方面的动机能力迄今仍未受到关注的化学依赖性。在这里,我们描述了被提名的大鼠赌博任务(CrGT) - 爱荷华赌博任务的rGT模拟的一个提示版本(Zeeb等,2009)。在这些任务中,动物选择与不同幅度和奖励频率相关的四个选项和惩罚超时期。像爱荷华州赌博任务一样,赞成与较小的每次审判奖励相关的选项,但损失较小,并避免诱人的“高风险,高回报”选项,从而最大限度地增加了这项任务的收益。至关重要的是,在CrGT中,显着的视听线索与蔗糖颗粒奖励的交付配对。这些提示的复杂性随着“赢”的大小而增加,类似于人类的赌博场景。最近的数据表明,添加这些奖励并发线索大大增加了适应不良的风险选择的选择,从而将选择偏离于动物的最佳利益。

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