Microdrill
Company: RWD Life Science
Catalog#: 78001
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Glioma Induction by Intracerebral Retrovirus Injection
Author:
Date:
2017-07-20
[Abstract]  Glioblastoma (GBM) is the most common primary brain cancer in adults and has a poor prognosis. It is characterized by a high degree of cellular infiltration that leads to tumor recurrence, atypical hyperplasia, necrosis, and angiogenesis. Despite aggressive treatment modalities, current therapies are ineffective for GBM. Mouse GBM models not only provide a better understanding in the mechanisms of gliomagenesis, but also facilitate the drug discovery for treating this deadly cancer. A ...

Microinjection of Virus into Lumbar Enlargement of Spinal Dorsal Horn in Mice
Author:
Date:
2016-11-20
[Abstract]  In order to explore the role of a specific gene/protein in the specific segment of spinal cord, the technique of intraspinal injection is particularly used to deliver viral vectors targeting the specific gene/protein. These viral vectors can knockdown or overexpress the specific gene/protein in specific cells (glial cells or neurons). In this protocol, lentivirus containing shRNA for CXCL13 were injected into dorsal horn of the spinal lumbar enlargement segment (Jiang et al., 2016). ...

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