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Author:
Date:
2014-06-05
[Abstract] After activation, T cells differentiate into different T helper (Th) subsets, namely Th1, Th2, and Th17. These different Th subsets are associated with the production of particular cytokines endowing them with different functions. In immunity against helminth infections the Th2 cell subset plays an important role. Th2 cells typically produce IL-4, IL-5, IL-13, and IL-9 resulting in antibody-isotype switching to IgE, eosinophilia, basophilia, mucin production, and smooth muscle cell hyperactivity. Here we analyze the development of the pathogen specific Th2 immune responses in mice after infection with the helminth parasite, Heligmosomoides polygyrus bakeri, the induction of innate lymphoid cells type 2 (ILC2) and the activation of the inflammasome in macrophages by ...
[摘要] 活化后，T细胞分化成不同的T辅助（Th）子集，即Th1，Th2和Th17。 这些不同的Th亚群与赋予它们不同功能的特定细胞因子的产生相关。 在抵抗蠕虫感染的免疫中，Th2细胞亚群起重要作用。 Th2细胞通常产生IL-4，IL-5，IL-13和IL-9，导致抗体同种型转换为IgE，嗜酸性粒细胞增多，嗜碱性粒细胞，粘蛋白产生和平滑肌细胞多动。 在这里我们分析感染后的蠕虫寄生虫，Heligmosomoides polygyrus bakeri，诱导的先天淋巴细胞2型（ILC2）和炎症小体的激活的病原体特异性Th2免疫反应的发展 巨噬细胞通过 Heligmosomoides polygyrus bakeri的排泄/分泌产物。
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