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N-ethylmaleimide

N-乙基马来酰亚胺

Company: Sigma-Aldrich
Catalog#: E2068
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Pulmonary Myeloperoxidase Activity
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Date:
2013-08-05
[Abstract]  Neutrophils are considered one of the first responders of the innate immune response. Their primary activities are to migrate to sites of infection by chemotaxis and trans-migration across the endothelium (Gaines et al., 2005). Once at the site of infection, they phagocytize microbes and kill them. Critical to the neutrophil’s ability to kill microbes are the multiple degradative enzymes contained within granules. The activity of these enzymes is non-specific, and therefore, neutrophils also contribute to tissue damage at the site of infection (Gaines and Berliner, 2005). Measurement of neutrophil infiltration into tissues is one way to gauge the severity of infection, inflammation, and tissue damage (Ayala et al., 2002). Myeloperoxidase is found in the primary granules ... [摘要]  嗜中性粒细胞被认为是先天免疫反应的第一反应者之一。 它们的主要活性是通过趋化性和穿过内皮的转移迁移到感染部位(Gaines等人,2005)。 一旦在感染的部位,他们吞噬微生物并杀死他们。 中性粒细胞杀死微生物的能力的关键是颗粒内包含的多种降解酶。 这些酶的活性是非特异性的,因此,嗜中性粒细胞也有助于感染部位的组织损伤(Gaines和Berliner,2005)。 中性粒细胞浸润到组织中的测量是测量感染,炎症和组织损伤的严重性的一种方式(Ayala等人,2002)。 髓过氧化物酶存在于嗜中性粒细胞的原始颗粒中,并且是嗜中性粒细胞浸润到组织中的有效量度(Gaines和Berliner,2005)。

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