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Author:
Date:
2012-12-20
[Abstract] Osteosarcomas are the most common primary, non-hematologic malignant tumors in childhood and adolescence, comprising almost 60% of all bone sarcomas. Although these tumors are osteoblastic in nature, the characteristics of the specific tumor-initiating cells are unclear. Osteosarcomas contain highly proliferative undifferentiated malignant cells with a disrupted bone differentiation program. Cancer stem cells (CSCs) that have tumor-initiating properties and capacity of symmetric and asymmetric division have now been described in many solid tumors. For osteosarcomas, the CSC hypothesis has received support from recently reported findings that both human and murine osteosarcomas contain a sub-population of multipotent cells that that express various mesenchymal stem cell surface markers and ...
[摘要] 骨肉瘤是儿童和青少年中最常见的原发性非血液恶性肿瘤，占所有骨肉瘤的近60％。虽然这些肿瘤在性质上是成骨细胞的，但是特异性肿瘤起始细胞的特征不清楚。骨肉瘤包含具有破坏的骨分化程序的高度增殖性未分化的恶性细胞。已经在许多实体瘤中描述了具有肿瘤起始性质和对称和不对称分裂能力的癌干细胞（CSC）。对于骨肉瘤，CSC假说已经从最近报道的发现获得支持，即人和鼠骨肉瘤包含表达多种间充质干细胞表面标志物的多能细胞亚群，并且能够在多种间充质谱系例如成骨细胞和脂肪细胞。通过在特定培养基中生长细胞并测定分化标记物，可以容易地评估分化为这些不同谱系。
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