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Author:
Date:
2015-11-20
[Abstract] Left ventricular (LV) remodeling occurs in many patients after myocardial infarction (MI). LV remodeling is characterized by progressive ventricular dilatation and contractile dysfunction, consequently to cardiomyocyte hypertrophy and fibrosis. Despite reperfusion therapies, this pathophysiological process is the main cause of cardiac evolution toward heart failure. Moreover, the outcome of patients after MI is largely dependent on the initial cardiac injury. Thus, this is of major clinical interest to develop new pharmacological strategies to limit infarct size and prevent or reverse left ventricular remodeling. Such preclinical cardiovascular treatments are often tested in rodents. The rat model of myocardial infarction is commonly used. In this model, the permanent ligation of the left ...
[摘要] 左心室（LV）重塑在心肌梗死（MI）后发生在许多患者中。 LV重塑的特征在于进行性心室扩张和收缩功能障碍，从而导致心肌细胞肥大和纤维化。尽管再灌注治疗，这种病理生理过程是心脏进入心力衰竭的主要原因。此外，MI后患者的结果主要取决于初始心脏损伤。因此，这是开发新的药理策略以限制梗死面积和防止或逆转左心室重塑的重大临床兴趣。这种临床前心血管治疗通常在啮齿动物中进行测试。通常使用大鼠心肌梗死模型。在该模型中，进行左前降支冠状动脉的永久性结扎（Bousquenaud等人，2013a）。
在用于这种手术技术和实验之后，操作者将需要每只大鼠从麻醉到大鼠恢复20分钟。
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