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Author:
Date:
2015-07-05
[Abstract] The cornea is an excellent model system to use for the analysis of wound repair because of its accessibility, lack of vascularization, and simple anatomy. Corneal injuries may involve only the superficial epithelial layer or may penetrate deeper to involve both the epithelial and stromal layers. Here we describe two well-established in vivo corneal wound models: a mechanical wound model that allows for the study of re-epithelialization and a chemical wound model that may be used to study stromal activation in response to injury (Stepp et al., 2014; Carlson et al., 2003).
[摘要] 角膜是一个优秀的模型系统，用于分析伤口修复，因为其可及性，缺乏血管化和简单的解剖结构。 角膜损伤可以仅涉及表面上皮层，或者可以更深地穿透以涉及上皮层和基质层。 在这里我们描述了两个建立良好的体内角膜伤口模型：允许研究重新上皮化的机械伤口模型和可用于研究基质激活以响应损伤的化学伤口模型 （Stepp等人，2014; Carlson等人，2003）。
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