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Author:
Date:
2015-11-05
[Abstract] Mature skeletal myofibers are elongated and multinucleated cells. Many stem/progenitor cell types, including committed muscle stem (satellite cells) and progenitor (myoblasts) cells, muscle-derived stem cells, myogenic endothelial cells, and mesenchymal stem/stromal cells, have been shown to exhibit skeletal myogenesis under appropriate inductive conditions. Committed muscle stem/progenitor cells and multipotent stem/progenitor cells which have skeletal myogenic capacity can typically be differentiated into skeletal myofibers in vitro following extended low-serum exposure. Differentiated cells exhibit distinct fiber-like elongated morphology with multiple nuclei and express unique muscle molecular markers indicating myogenesis, including desmin (early) and fast- and/or ...
[摘要] 成熟骨骼肌纤维是细长和多核细胞。 许多干/祖细胞类型，包括定型肌干（卫星细胞）和祖细胞（成肌细胞）细胞，肌肉衍生的干细胞，肌肉内皮细胞和间充质干/基质细胞，已显示在适当的诱导条件下表现出骨骼肌发生 。 具有骨骼肌生成能力的承诺的肌肉干/祖细胞和多能干/祖细胞可以在延长的低血清暴露后通常在体外分化成骨骼肌纤维。 分化的细胞表现出不同的纤维样细长形态与多个核，并表示独特的肌肉分子标记指示肌发生，包括结蛋白（早）和快和/或慢肌球蛋白重链（成熟）。
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