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Author:
Date:
2015-03-05
[Abstract] Bacterial biofilms are associated clinically with many bacterial infections including those caused by bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus. In recent years, extracellular vesicles produced by bacteria have been isolated from biofilm communities. Vesicles have been described in depth and can encapsulate various virulence factors including toxins and immunomodulatory compounds. Vesicles may be important for virulence and survival by serving as a vehicle for the secretion and concentrated delivery of these molecules. Studying extracellular vesicles is an important step towards understanding biofilm formation, structure, and disruption with the ultimate goal of preventing or treating hospital infections caused by bacterial pathogens residing in ...
[摘要] 细菌生物膜临床上与许多细菌感染相关，包括由细菌如绿脓杆菌和金黄色葡萄球菌引起的细菌感染。 近年来，由细菌产生的胞外囊泡已经从生物膜群落中分离。 囊泡已经被深入描述并且可以包封各种毒力因子，包括毒素和免疫调节化合物。 通过作为这些分子的分泌和浓缩递送的载体，囊泡可能对于毒力和存活是重要的。 研究胞外囊泡是理解生物膜形成，结构和破裂的重要步骤，其最终目的是预防或治疗由存在于生物膜中的细菌病原体引起的医院感染。 在这里我们描述了从枯草芽孢杆菌生产的生物膜中分离囊泡的方案。
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