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Author:
Date:
2014-11-20
[Abstract] Inflammatory bowel disease (IBD) including Crohn’s disease and ulcerative colitis are characterized by chronic, progressive and relapsing inflammatory disorders. Existing evidence indicate that IBD is associated with a higher risk of developing CAC, which is directly related to the duration and extent of colitis. Thus, animal models have been developed to understand the biology of colitis and CAC. The most commonly used model of colitis is to treat with dextran sodium sulfate (DSS). DSS given in the drinking water is toxic to the colonic epithelial lining and induces bloody diarrhea, ulceration and inflammation, similar to colitis in IBD patients. To study CAC, DSS treatment is combined with a single intraperitoneal injection of the DNA alkylation reagent Azoxymethane (AOM).
[摘要] 包括克罗恩病和溃疡性结肠炎的炎性肠病（IBD）的特征在于慢性，进行性和复发性炎症性疾病。 现有证据表明IBD与发展CAC的较高风险相关，其与结肠炎的持续时间和程度直接相关。 因此，已经开发了动物模型来理解结肠炎和CAC的生物学。 最常用的结肠炎模型是用葡聚糖硫酸钠（DSS）治疗。 在饮用水中给予的DSS对结肠上皮衬里有毒并且诱导血性腹泻，溃疡和炎症，类似于IBD患者的结肠炎。 为了研究CAC，将DSS治疗与单次腹膜内注射DNA烷基化试剂偶氮甲烷（AOM）组合。
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