| Glioma Associated Stem Cells (GASCs) Isolation and Culture
|
|
Author:
Date:
2015-05-05
[Abstract] Glioma Associated Stem Cells (GASCs) represent a population of non-tumorigenic multipotent stem cells hosted in the microenvironment of human gliomas. In vitro, these cells are able, through the release of exosomes, to increase the biological aggressiveness of glioma-initiating cells. The clinical importance of this finding is supported by the strong prognostic value associated with the GASCs surface immunophenotype thus suggesting that this patient-based approach can provide a groundbreaking method to predict prognosis and to exploit novel strategies that target the tumor stroma (Bourkoula et al., 2014).
[摘要] 胶质瘤相关干细胞（GASC）代表在人类神经胶质瘤的微环境中存在的非致瘤性多能干细胞群体。 在体外，这些细胞能够通过外来体的释放增加胶质瘤起始细胞的生物攻击性。 该发现的临床重要性得到与GASCs表面免疫表型相关的强预后价值的支持，因此表明这种基于患者的方法可以提供开创性的方法来预测预后并开发靶向肿瘤基质的新策略（Bourkoula等人， et al。，2014）。
|
|
|
| Generation of Mouse Bone Marrow-Derived Macrophages (BM-MFs)
|
|
Author:
Date:
2012-06-20
[Abstract] Generating mouse macrophages from bone-marrow progenitor cells is a useful tool to study biological functions of mouse macrophages. Macrophages are one of the major populations of phagocytes and play many different roles during inflammatory process initiation and termination.
[摘要] 从骨髓祖细胞产生小鼠巨噬细胞是研究小鼠巨噬细胞的生物学功能的有用工具。 巨噬细胞是吞噬细胞的主要种群之一，并在炎症过程开始和终止期间发挥许多不同的作用。
|
|
|
| Generation of Mouse Bone Marrow-Derived Dendritic Cells (BM-DCs)
|
|
Author:
Date:
2012-06-20
[Abstract] Generating mouse dendritic cells from bone-marrow progenitor cells is a useful tool to study biological functions of mouse dendritic cells. Dendritic cells are one of the major populations of phagocytes able to activate both innate and adaptive immune cells.
[摘要] 从骨髓祖细胞产生小鼠树突细胞是研究小鼠树突细胞的生物学功能的有用工具。 树突细胞是能够激活先天和适应性免疫细胞的吞噬细胞的主要群体之一。
|
|
|