D.P.X.
Company: Sigma-Aldrich
Catalog#: 317616
Product evaluation:
Three Dimensional Spheroid Co-culture Invasion Assay
Author:
Date:
2015-01-05
[Abstract]  The assay was developed to investigate the impact of stromal cells of different types (in our case breast cancer associated fibroblasts stably manipulated to modify expression of genes of interest) on the invasive capacity of epithelial cancer cells (in our case breast cancer cell lines) (Verghese et al., 2013). Typical two dimensional invasion assays do necessarily account for the presence of extracellular matrix that is present around the stromal and tumour cells in vivo and ...

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