|
Author:
Date:
2012-03-05
[Abstract] Cell adhesion, the binding of a cell to the extracellular matrix (ECM), other cells, or a specific surface, is essential for the growth and survival of the cell and also its communication with other cells. The process of cell adhesion involves a range of biological events such as three-dimensional re-organization of the cytoskeleton, biochemical reactions in the cell, and changes in molecules on the surface of the cell. Cancer cells, especially the highly metastatic types, are believed to have enhanced adhesion ability that often facilitates the migration of the cells to a new site to establish new tumors in the body. Cell adhesion assay is therefore often used to evaluate the metastatic ability of cancer cells. In addition, the assay can also be used to assess the effect of certain ...
[摘要] 细胞粘附，细胞与细胞外基质（ECM），其他细胞或特定表面的结合对于细胞的生长和存活以及其与其它细胞的连通是必需的。细胞粘附的过程涉及一系列生物事件，例如细胞骨架的三维重组，细胞中的生化反应和细胞表面上分子的变化。癌细胞，特别是高度转移的类型，被认为具有增强的粘附能力，通常促进细胞迁移到新的位置以在体内建立新的肿瘤。因此，细胞粘附测定常用于评价癌细胞的转移能力。此外，该测定也可以用于评价某些治疗（例如，暴露于化学品）对细胞粘附能力的影响。本文描述了修饰的细胞粘附测定方案，用于研究细胞和细胞外物质之间的相互作用。
|