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Author:
Date:
2016-10-05
[Abstract] HER2 is a tyrosine kinase receptor, which is overexpressed in about 30% of breast cancer patients. Its overexpression leads to mammary tumorigenesis and increased invasion and metastasis (Slamon et al., 1987). HER2 transgenic mouse (FVB/N-MMTVneu mouse) is a well-established model of mammary tumor in human (Fantozzi and Christofori, 2006). Although in vivo models are excellent for assessing the influence of various factors, especially microenvironment, on development of breast cancer, a convenient and less costly way to study the underlying molecular events is utilizing cells derived from the model under evaluation. In order to explore the molecular mechanism by which HOXB7 inhibits initiation, but promotes metastasis of breast tumors, we generated mouse breast cancer ...
[摘要] HER2是酪氨酸激酶受体，其在约30％的乳腺癌患者中过表达。 其过表达导致乳腺肿瘤发生和增加的侵袭和转移（Slamon等人，1987）。 HER2转基因小鼠（FVB/N-MMTVneu小鼠）是人类乳腺肿瘤的良好建立的模型（Fantozzi和Christofori，2006）。 虽然体内模型对于评估各种因素，特别是微环境对乳腺癌发展的影响是极好的，但是一种方便且成本较低的研究基础分子事件的方法是利用来自模型的细胞 评价。 为了探索HOXB7抑制起始，但促进乳腺肿瘤转移的分子机制，我们从HER2转基因小鼠产生小鼠乳腺癌细胞系（Liu等人，2015）。 该方案可用于从具有其他遗传背景的小鼠产生乳腺癌细胞系。
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