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Author:
Date:
2015-01-20
[Abstract] Drug-induced mitochondrial injury can be caused by many different mechanisms including inhibition of mitochondrial DNA replication, transcription, translation, and altered protein function. Determination of the level of mitochondrial protein synthesis, or mitochondrial biogenesis, relative to the cellular protein synthesis, provides important information on potential mitochondrial toxicity.
[摘要] 药物诱导的线粒体损伤可以由许多不同的机制引起，包括线粒体DNA复制，转录，翻译和改变的蛋白质功能的抑制。 相对于细胞蛋白质合成的线粒体蛋白质合成水平或线粒体生物发生的确定提供了关于潜在线粒体毒性的重要信息。
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