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Author:
Ying Wu, MyungSam Cho, David Shore, Manki Song, JungAh Choi, Tao Jiang, Yong-Qiang Deng, Melissa Bourgeois, Lynn Almli, Hua Yang, Li-Mei Chen, Yi Shi, Jianxu Qi, An Li, Kye Sook Yi, MinSeok Chang, Jin Soo Bae, HyunJoo Lee, JiYoung Shin, James Stevens, SeoungSuh Hong, Cheng-Feng Qin, George F. Gao, Shin Jae Chang and Ruben O. Donis,
Date:
2016-06-05
[Abstract] Heamagglutination is inhibited when antibodies are present because antibodies to the influenza virus will prevent attachment of the virus to red blood cells. The highest dilution of antibody that prevents hemagglutination is called the HI titer. Human monoclonal antibodies generated from single human B cells were tested to characterize their ability to inhibit hemagglutination against virus A/California/07/2009 (H1N1) and A/Brisbane/10/2007 (H3N2).
[摘要] 当存在抗体时，凝血抑制被抑制，因为针对流感病毒的抗体将阻止病毒附着于红细胞。 防止血细胞凝集的抗体的最高稀释度称为HI滴度。 测试从单个人B细胞产生的人单克隆抗体，以表征其抑制关于病毒A/California/07/2009（H1N1）和A/Brisbane/10/2007（H3N2）的凝血的能力。
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Author:
Ying Wu, MyungSam Cho, David Shore, Manki Song, JungAh Choi, Tao Jiang, Yong-Qiang Deng, Melissa Bourgeois, Lynn Almli, Hua Yang, Li-Mei Chen, Yi Shi, Jianxu Qi, An Li, Kye Sook Yi, MinSeok Chang, Jin Soo Bae, HyunJoo Lee, JiYoung Shin, James Stevens, SeoungSuh Hong, Cheng-Feng Qin, George F. Gao, Shin Jae Chang and Ruben O. Donis,
Date:
2016-06-05
[Abstract] The human monoclonal antibodies generated from single human B cells were tested to characterize their ability to neutralize virus infectivity. The microneutralization assay is a highly sensitive and specific assay for detecting virus-specific neutralizing antibodies to influenza viruses. This protocol is to measure the ability of human monoclonal antibody to neutralize influenza virus by microneutralization assay.
[摘要] 测试从单个人B细胞产生的人单克隆抗体，以表征其中和病毒感染性的能力。 微量中和测定法是用于检测流感病毒的病毒特异性中和抗体的高度灵敏和特异性的测定法。 该方案是测量人单克隆抗体通过微量中和测定中和流感病毒的能力。
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